M
MCP Directory CURATED DIRECTORY
911 MCP servers indexed
中文
← Back to directory
COMPARE UP TO 4 SERVERS

Compare MCP servers

Compare scores, permissions, risks, and fit in one decision-focused table.

DimensionCUGA Generalist Agent HarnessA configurable generalist agent harness for the enterpriseBioMCPOne binary. One grammar. Evidence from the biomedical sources you already trust.
FMRS49 / 100 · D75 / 100 · B
Reliability8 / 2010 / 20
Security and permissions7 / 2016 / 20
Maintenance12 / 2018 / 20
Documentation13 / 2017 / 20
Setup experience9 / 2014 / 20
Best for
  • Enterprise agent teams that need governable, auditable policies
  • Developers who want a generalist agent they only configure with domain tools and policies
  • Hybrid workflows that must combine browser interaction with API calls
  • Teams using the Python SDK or self-hosting on Kubernetes
  • Biomedical researchers
  • Clinicians
  • AI agents that need efficient access to biomedical literature and data analysis
Not for
  • Lightweight scenarios that only need a single simple tool call
  • Offline users who cannot supply any LLM API key or self-hosted model
  • End users expecting zero-configuration out-of-the-box use
  • Users needing to write to upstream databases (read-only)
  • Users requiring direct access to closed datasets (e.g., COSMIC is not directly integrated)
  • Users expecting all advanced features without API keys
Required permissions
  • Reading the repository and local workspace files (e.g. files under cuga_workspace)
  • Network access to LLM providers, OpenAPI services, and MCP servers
  • In hybrid/web mode, controlling browser pages through the browser extension and Playwright
  • Accessing Docker/Podman or E2B cloud execution environments when sandboxing is enabled
  • In manage mode, drafting and publishing agent configuration (tools, MCP, LLM, policies)
  • Requires internet access to query public biomedical APIs
  • Optional API keys (NCBI, Semantic Scholar, OpenFDA, etc.) to improve rate limits or unlock features
  • Local read/write access for skills, cache, and local study data (e.g., `~/.local/share/biomcp`)
Risks and side effects
  • The agent can call real APIs and act on web pages on the user's behalf, so mistakes can have real business impact
  • Misconfigured policies or sandboxes weaken isolation; local Python execution is the default and is less isolated
  • Exposing the local registry to E2B via tunnels such as ngrok increases the attack surface
  • The knowledge base and saved trajectories may contain sensitive enterprise data that you must store and access-control yourself
  • Runs against self-hosted or internal models, so token and cost accounting must be converted with your own rates
  • Upstream API rate limits may affect performance
  • Some data sources (e.g., KEGG) have licensing terms that restrict non-academic use
  • Features requiring API keys (e.g., OncoKB) may be incomplete without them
  • Local binary installations need regular updates for compatibility
Supported clientsCUGA SDK, MCPClaude Desktop, Claude Code, Codex, Other MCP stdio clients
Tools211