Best for
- Researchers needing local-first and reproducible bioinformatics workflows
- Users who want an AI agent to orchestrate existing bioinformatics skills
- Developers learning genome-analysis workflows with demo data
C
63FMRS · C
The supplied sources identify a PyPI MCP package at version 0.6.1 with a stdio configuration example. The server defaults to demo data and offers an optional local-file access switch; no specific MCP tool names are listed in the supplied manifest.
ClawBio is a bioinformatics-native AI agent skill library covering pharmacogenomics, GWAS, variant interpretation, ancestry, single-cell, and RNA-seq. Its MCP server runs locally over stdio, defaults to demo data, and states that genomic data is not sent off the machine by default.
Tools
The tool list has not been reviewed yet.
Setup
With Python 3.11+ available, add the configuration to an MCP-compatible client using the provided uvx command. The server uses demo data by default. Set CLAWBIO_MCP_ALLOW_LOCAL_FILES=1 if skills need to read or write local files.
claude_desktop_config.json
{"mcpServers":{"clawbio":{"command":"uvx","args":["--from","clawbio[mcp]","clawbio","mcp"]}}}
Fit and risk
Not for
- Users seeking a general database, cloud-storage, or browser-automation server
- Clinical diagnosis or prescribing decisions
- Use cases that require direct patient-genome access by default
Required permissions
- The default mode runs demo data only
- With CLAWBIO_MCP_ALLOW_LOCAL_FILES=1, skills may read and write local files
- Depending on the skill invoked, some workflows access external annotation, genomic, or Galaxy services
Risks and side effects
- Pharmacogenomic and clinical-variant results should not replace professional medical judgment
- After local-file access is enabled, skills may process or write input and output files
- Skills using external APIs or Galaxy may send relevant queries or data to external services
- Some reproductions require the original external inputs or external tools to remain available
Troubleshooting
- Confirm Python 3.11+ and uvx are installed
- Check the client configuration command, arguments, and JSON syntax
- Validate the connection first with the default demo mode
- If local files are required, confirm CLAWBIO_MCP_ALLOW_LOCAL_FILES=1 is set
- For skills requiring external services, check that the required services, tools, and credentials are configured
Use cases
Run pharmacogenomics and variant-annotation analyses
Query genomic resources including GWAS Catalog, ClinVar, and gnomAD
Run ancestry PCA, polygenic risk, single-cell, and RNA-seq workflows
Produce reproducibility outputs containing commands, environment metadata, and checksums
Supported clients
CursorPartial support
ZedPartial support
VS CodePartial support
Claude DesktopPartial support